Journal article
Apolipoprotein e gene associations in age-related macular degeneration
MKM Adams, JA Simpson, AJ Richardson, DR English, KZ Aung, GA Makeyeva, RH Guymer, GG Giles, J Hopper, LD Robman, PN Baird
American Journal of Epidemiology | Published : 2012
DOI: 10.1093/aje/kwr329
Abstract
The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported associations have been questioned, as they are opposite those for Alzheimer's disease and cardiovascular disease. The authors examined associations between APOE genotype and AMD using a case-control study (2,287 cases and 2,287 controls individually matched on age, sex, and country of origin) nested within Melbourne Collaborative Cohort Study participants aged 48-86 years at AMD detection. The odds ratio for early AMD among participants with ε2-containing genotypes (ε2ε2/ε2ε3/ε2ε4) was 1.32 (95% confidence interval (CI): 1.11, 1.58; P = 0.002) versus persons with genotype ε3..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Funding Acknowledgements
This work was supported by VicHealth; the Cancer Council Victoria (initial cohort recruitment); and the National Health and Medical Research Council of Australia (NHMRC) (program grant 209057, capacity-building grant 251533, and enabling grant 396414). The ophthalmic component of the study was funded by the Ophthalmic Research Institute of Australia, the American Health Assistance Foundation, the John Reid Charitable Trust, the Perpetual Trustees, and the Royal Victorian Eye and Ear Hospital. Support was also provided through the awarding of an NHMRC Practitioner Fellowship to R. H. G., a Wagstaff Fellowship to L. D. R., and an NHMRC PhD Scholarship and Hugh Noel Puckle Scholarship to M. K. M. A. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian government.